The –514 polymorphism in the hepatic lipase gene (LIPC) does not influence androgen-mediated stimulation of hepatic lipase activity
نویسندگان
چکیده
منابع مشابه
Body mass index and hepatic lipase gene (LIPC) polymorphism jointly influence postheparin plasma hepatic lipase activity.
The -514 polymorphism in the hepatic lipase gene (LIPC) is associated with decreased hepatic lipase activity. In the present study, the interaction between body mass index (BMI), the -514 polymorphism, and hepatic lipase activity was examined in 118 white men and in 51 African American men. BMI was significantly positively correlated with hepatic lipase activity in both populations. BMI was sim...
متن کاملTranscriptional regulation of the human hepatic lipase (LIPC) gene promoter.
Hepatic lipase (HL) plays a key role in the metabolism of plasma lipoproteins, and its level of activity requires tight regulation, given the association of both low and high levels with atherosclerosis and coronary artery disease. However, little is known about the factors responsible for HL expression. Here, we report that the human hepatic lipase gene (LIPC) promoter is regulated by hepatocy...
متن کاملLack of association between LIPC-514 C/T polymorphism of hepatic lipase and endometriosis in Iranian women.
AIM Patients with endometriosis may suffer from dyslipidemia. Hepatic lipase (HL) is involved in the metabolism of lipoproteins and has an important role in reverse cholesterol transport. The aim of this study was to investigate the association between the LIPC-514 C/T polymorphism in the HL gene and the risk of endometriosis in a group of Iranian women. METHODS Ninety-seven patients with end...
متن کاملPrimary prevention of coronary heart disease: guidance from Framingham: a statement for healthcare professionals from the AHA Task Force on Risk Reduction. American Heart Association.
1. Cholesterol management in high-risk patients without heart disease. When is lipid-lowering medication warranted for primary prevention? Grundy SM. 3. The role of cholesterol management in coronary disease risk reduction in elderly patients. [PubMed-indexed for MEDLINE]Related citations 4. Mapping a gene involved in regulating dietary cholesterol absorption. The sitosterolemia locus is found ...
متن کاملA hepatic lipase gene promoter polymorphism attenuates the increase in hepatic lipase activity with increasing intra-abdominal fat in women.
High hepatic lipase (HL) activity is associated with an atherogenic lipoprotein profile of small, dense LDL particles and lower HDL(2)-C. Intra-abdominal fat (IAF) is positively associated with HL activity. A hepatic lipase gene (LIPC) promoter variant (G-->A(-250)) is associated with lower HL activity, higher HDL(2)-C, and less dense LDL particles. To determine whether the LIPC promoter polymo...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1998
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)32534-7